Digital Monitoring Framework for Comparative Assessment of Bacterial Cellulose-Based Biomaterial Wound Therapy

Murotov, Nurshod; Sapiokhunova, Khilola; Utamuradova, Nigora; Yussupov, Zaynab

doi:Under indexing

Proceedings of International Conference on Applied Innovation in IT · 2026/07/22 · Vol. 14 · Issue 4 · pp. 1545–1550

Digital Monitoring Framework for Comparative Assessment of Bacterial Cellulose-Based Biomaterial Wound Therapy

Nurshod Murotov, Khilola Sapiokhunova, Nigora Utamuradova, Zaynab Naimova and Rustam Yussupov

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Abstract

Acute purulent infections remain a major clinical problem due to persistent microbial contamination, prolonged inflammation, and delayed tissue repair. The limited effectiveness of conventional local therapies necessitates the development of advanced biomaterials and objective assessment tools. Bacterial cellulose (BC), especially when combined with MXene nanostructures, represents a promising approach for enhancing antimicrobial and reparative outcomes, while digital monitoring technologies allow integrated and dynamic evaluation of treatment effectiveness. In this study, we assessed the effectiveness of bacterial cellulose-based BC-MXene biomaterials in the local treatment of experimentally induced mixed-etiology purulent infections using these digital monitoring technologies. An experimental study was conducted on outbred white rats with acute purulent infection induced by Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Animals were divided into three groups: BC-MXene biocomposite, bacterial cellulose-only, and conventional local therapy, with microbiological, immunological, hematological, and morphological parameters assessed over 14 days. A digital monitoring system was successfully used to integrate longitudinal data and calculate a composite effectiveness index. As a result, the BC-MXene group demonstrated faster and greater reduction in bacterial load compared with the BC-only and control groups, alongside immune response normalization and a more pronounced decrease in pro-inflammatory activity. Histological analysis revealed accelerated inflammation resolution, enhanced granulation tissue formation, active angiogenesis, and earlier epithelialization, leading to the highest integrated digital effectiveness index in the BC-MXene group. Ultimately, bacterial cellulose-based BC-MXene biomaterials show high antibacterial, immunomodulatory, and reparative effectiveness in experimental purulent infection, proving that digital monitoring technologies provide an objective and integrated approach for evaluating treatment outcomes and support the further development of BC-MXene biomaterials for advanced local wound management.

Keywords

Bacterial Cellulose MXene Purulent Infection Biomaterials Digital Monitoring Local Wound Therapy

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