Proceedings of International Conference on Applied Innovation in IT  ·  2026/06/12  ·  Vol. 14  ·  Issue 4  ·  pp. 653–659
Physics-Informed Deep Learning for Blood Flow and Oxygen Transport Modeling in Human Physiology
Fatimah Kadhim Ibrahim Al-Mahdawi, Ammar Kadi, Hassan Al-Mahdawi and Hassan Hadi Saleh
Coupled transport processes like blood flow and oxygen delivery are important for cellular metabolism and organ function in the human body. Nonlinear partial differential equations (PDEs) that describe convection, diffusion, and biochemical reactions control these processes. Conventional numerical methods, including finite difference and finite element techniques, necessitate dense discretization and comprehensive boundary data, thereby constraining their efficacy in realistic biomedical contexts characterized by sparse or noisy measurements. This research suggests a physics-informed deep learning framework for simulating blood flow and oxygen transport in human physiology. The method uses Physics-Informed Neural Networks (PINNs) to put the governing PDEs directly into the training process. This lets the model learn physically consistent solutions without needing a lot of labeled data. The framework combines a simplified hemodynamic model with a convection-diffusion-reaction equation that shows how oxygen moves through and is used by tissues. The suggested method doesn't use any meshes and is data efficient. It can work with irregular domains and incomplete data. It is a flexible tool for simulating the delivery of oxygen in cardiovascular and tissue-level systems. It could also be used for inverse modeling and patient-specific analysis. The results show that the approximations are correct and stable, and they don't rely as much on high-resolution data. This supports advanced uses like digital twins and personalized medicine.
Physics-Informed Neural Networks (PINNs) Human Physiology Modeling Oxygen Transport Blood Flow Dynamics Convection-Diffusion-Reaction Equations Partial Differential Equations (PDEs)
References
  1. Alfio Quarteroni, M. Tuveri, and A. Veneziani, “Computational vascular fluid dynamics: Problems, models and methods,” Computing and Visualization in Science, vol. 2, no. 4, pp. 163-197, 2000.
  2. Jean Donea and Antonio Huerta, Finite Element Methods for Flow Problems. Chichester, U.K.: Wiley, 2003.
  3. Randall J LeVeque, Finite Volume Methods for Hyperbolic Problems. Cambridge, U.K.: Cambridge University Press, 2002.
  4. James Keener and James Sneyd, Mathematical Physiology. New York, NY, USA: Springer, 2009.
  5. Gerhard A Holzapfel, Nonlinear Solid Mechanics: A Continuum Approach for Engineering. Chichester, U.K.: Wiley, 2000.
  6. Thomas J R Hughes, The Finite Element Method: Linear Static and Dynamic Finite Element Analysis. Dover, 2000.
  7. Ian Goodfellow, Yoshua Bengio, and Aaron Courville, Deep Learning. Cambridge, MA, USA: MIT Press, 2016.
  8. Justin Sirignano and Konstantinos Spiliopoulos, “A deep learning algorithm for solving partial differential equations,” Journal of Computational Physics, vol. 375, pp. 1339-1364, 2018.
  9. Maziar Raissi, Paris Perdikaris, and George Em Karniadakis, “Physics-informed neural networks: A deep learning framework for solving forward and inverse problems involving nonlinear partial differential equations,” Journal of Computational Physics, vol. 378, pp. 686-707, 2019.
  10. George Em Karniadakis et al., “Physics-informed machine learning,” Nature Reviews Physics, vol. 3, pp. 422-440, 2021.
  11. Zhiping Mao, Ameya D Jagtap, and George Em Karniadakis, “Physics-informed neural networks for high-speed compressible flows,” Computer Methods in Applied Mechanics and Engineering, vol. 360, 2020.
  12. Sheng Wang, Y. Teng, and Paris Perdikaris, “Understanding and mitigating gradient pathologies in physics-informed neural networks,” SIAM Journal on Scientific Computing, vol. 43, no. 5, pp. A3055-A3081, 2021.
  13. Ameya D Jagtap, E. Kharazmi, and George Em Karniadakis, “Extended physics-informed neural networks (XPINNs): A generalized space-time domain decomposition framework,” Communications in Computational Physics, vol. 28, no. 5, pp. 2002-2041, 2020.
  14. Lu Lu et al., “DeepXDE: A deep learning library for solving differential equations,” SIAM Review, vol. 63, no. 1, pp. 208-228, 2021.
  15. Ehsan Kharazmi, Z. Zhang, and George Em Karniadakis, “hp-VPINNs: Variational physics-informed neural networks with domain decomposition,” Computer Methods in Applied Mechanics and Engineering, vol. 374, 2021.
  16. George Kissas et al., “Machine learning in cardiovascular flows modeling: Predicting arterial blood pressure from non-invasive 4D flow MRI,” Nature Machine Intelligence, vol. 2, pp. 713-721, 2020.
  17. [Alireza Yazdani et al., “A generalizable physics-informed neural network for blood flow and oxygen transport in microvascular networks,” PLoS Computational Biology, vol. 16, no. 8, 2020.


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