The article examines the issues of modern information technologies (IT) and their application in higher education institutions. The purpose of the article is to analyze the main areas of application of IT in the digital ecosystem of a higher education institution, covering educational process management, teaching and learning, and scientific research. Comparative, systemic, and structural-functional methods are used to conduct the study. The evolution of IT in education is briefly highlighted from the invention of the printing press to the formation of modern digital ecosystems. The main areas of IT application in higher education institutions are as follows: automation of management and administrative processes; computerization of the educational process; creation of an interactive learning environment; and integration of information and communication technologies into scientific and research activities. Modern IT solutions for each area are described. The practical experience of the Vinnytsia Institute of Trade and Economics of the State University of Trade and Economics is presented as a case study of an integrated digital ecosystem built on its automated management system “Smart Electronic Learning,” and the Moodle educational platform. It is emphasized that the maximum effect of digital transformation is achieved not through the mechanical implementation of individual technologies, but their organic integration into a single digital ecosystem. An integrated approach to implementing IT ensures data integration, eliminates information duplication, and creates a synergistic effect for all participants in the educational process.