The article analyzes the transformation of higher education in the era of Artificial Intelligence (AI) in the context of digital learning practices and cultural changes within the university environment. The aim of the study is to understand the impact of AI technologies on institutional models of universities and everyday learning practices. The methodological basis of the work is an interdisciplinary approach that combines cultural and pedagogical analysis with a comparative study of digital educational platforms. Special attention is paid to the role of AI as a tool for personalized learning, learning analytics, and the automation of educational and managerial processes, as well as to issues of ethics, autonomy, and cultural responsibility. The practical part of the article includes a comparative analysis of the distance learning systems Moodle and Google Classroom, using the case of the Odesа Polytechnic National University. It is shown that these platforms represent different models of organizing digital learning: a functionally oriented LMS with a high level of customization, and a cloud-based distance learning system focused on interface convenience and user experience. The results of the study confirm that the integration of AI into higher education is not only a technological but also a cultural process, which requires rethinking academic roles, educational strategies, and the value foundations of universities.